| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 40511140 | Correlation of Vitamin D in Different Stages of Hypertension as Per JNC 8 Criteria |
| Magnesium | 📋 | ✍ | ⛔ | | 37821564 | Associations between dietary magnesium intake and hypertension, diabetes, and hyperlipidemia |
| L-Arginine | 📋 | ✍ | ⛔ | | 39980190 | L-arginine ameliorates hypertension and cardiac mitochondrial abnormalities but not cardiac injury in male metabolic syndrome rats |
| Cocoa | 📋 | ✍ | ⛔ | | 40249472 | The Cardiovascular Benefits of Dark Chocolate Supplementation before High-Intensity Resistance Exercise in the Early Follicular and Mid-Luteal Phases of the Menstrual Cycle |
| Roselle | 📋 | ✍ | ⛔ | | 39870328 | Efficacy and safety of Hibiscus sabdariffa in cardiometabolic health: An overview of reviews and updated dose-response meta-analysis |
| Resveratrol | 📋 | ✍ | ⛔ | | 38447888 | Ameliorative effect of resveratrol on acute ocular hypertension induced retinal injury through the SIRT1/NF-κB pathway |
| Melatonin | 📋 | ✍ | ⛔ | | 40538465 | Melatonin Improves Quality of Life, Oxidative Stress, and Cardiovascular Function in Pulmonary Arterial Hypertension |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 40341867 | Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension |
| Beets | 📋 | ✍ | ⛔ | | 40324575 | Exploring sodium nitrate supplementation in enhancing nitric oxide bioavailability and reducing oxidative stress: implications for blood pressure and endothelial dysfunction in hypertension |
| Quercetin | 📋 | ✍ | ⛔ | | 40259964 | Perillyl alcohol, quercetin, and berberine combination therapy ameliorates experimental pulmonary arterial hypertension: Effects on the lung miR-204 expression, remodeling, and inflammatory factors |
| Vitamin C | 📋 | ✍ | ⛔ | | 40181943 | Interactive effect between Selenium and Vitamin C levels on risk of hypertension among adult women in the United States: evidence from NHANES 2011 to 2020 |
| Curcumin | 📋 | ✍ | ⛔ | | 39265778 | The effect of curcumin supplementation on endothelial function and blood pressure in patients with metabolic disorders: A meta-analysis of meta-analyses |
| Pomegranate | 📋 | | ⛔ | | 40218993 | Effects of Pomegranate Extract on Inflammatory Markers and Cardiometabolic Risk Factors in Adults Aged 55-70 Years: A Randomised Controlled Parallel Trial |
| Food | 📋 | | | | 40401063 | Dietary patterns and hypertension in Chinese adults: a systematic review and meta-analysis |
| Micronutrients | 📋 | | ⛔ | | 39505584 | Lifestyle modifications and non-pharmacological management in elderly hypertension |
| CoQ10 | 📋 | ✍ | ⛔ | | 40495903 | Effects of coenzyme Q10 administration on blood pressure and heart rate in adults: A systematic review and meta-analysis of randomized controlled trials |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 39262749 | Therapeutic potential of Omega-3 polyunsaturated fatty acids on the immune function of patients with hypertensive disorder complicating pregnancy and preeclampsia |
| Hesperidin | 📋 | ✍ | ⛔ | | 40110966 | Potential Role of Hesperidin in Improving Experimental Pulmonary Arterial Hypertension in Rats via Modulation of the NF-?B Pathway |
| L-Citrulline | 📋 | ✍ | ⛔ | | 39385595 | Acute Effects of Citrulline Malate Supplementation on Nocturnal Blood Pressure Dipping After Exercise in Hypertensive Patients: A Randomized, Placebo-Controlled Trial |
| Berberine | 📋 | ✍ | ⛔ | | 40259964 | Perillyl alcohol, quercetin, and berberine combination therapy ameliorates experimental pulmonary arterial hypertension: Effects on the lung miR-204 expression, remodeling, and inflammatory factors |
| Puerarin | 📋 | ✍ | ⛔ | | 39203718 | Puerarin Alleviates Blood Pressure via Inhibition of ROS/TLR4/NLRP3 Inflammasome Signaling Pathway in the Hypothalamic Paraventricular Nucleus of Salt-Induced Prehypertensive Rats |
| Aged Garlic | 📋 | ✍ | ⛔ | | 39437887 | Effects of Aged Garlic Extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials |
| Astragalosides | 📋 | ✍ | ⛔ | | 40582717 | Astragaloside IV Improves Pulmonary Vascular Endothelial Dysfunction in Pulmonary Arterial Hypertension by Inhibiting Ferroptosis through Modulation of the Calpain-1/TGF-?/TFRC Pathway |
| Blueberry | 📋 | ✍ | ⛔ | | 40218902 | Blueberry Extract and Resistance Training Prevent Left Ventricular Redox Dysregulation and Pathological Remodeling in Experimental Severe Pulmonary Arterial Hypertension |
| Cannabidiol | 📋 | ✍ | ⛔ | | 39351852 | Chronic cannabidiol treatment induces cardiovascular improvement in renovascular hypertensive rats |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 40325976 | Efficacy of Olive Leaf Extract in Improving Blood Pressure in Pre-Hypertensive and Hypertensive Individuals: A Systematic Review and Meta-Analysis |
| Pine Bark | 📋 | ✍ | ⛔ | | 36280012 | Effect of a polyphenol-rich dietary supplement containing Pinus Massoniana bark extract on blood pressure in healthy adults: a parallel, randomized placebo-controlled trial |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 37433173 | Combined use of amlodipine and folic acid are significantly more efficacious than amlodipine alone in lowering plasma homocysteine and blood pressure among hypertensive patients with hyperhomocysteinemia and intolerance to ACEI: A multicenter, randomized, double-blind, parallel-controlled clinical trial |
| Chokeberry | 📋 | ✍ | ⛔ | | 36228567 | The effects of Aronia berry (poly)phenol supplementation on arterial function and the gut microbiome in middle aged men and women: Results from a randomized controlled trial |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 40219017 | Moringa oleifera and Blood Pressure: Evidence and Potential Mechanisms |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 40338252 | Cardiometabolic Effects of Nigella sativa in Postmenopausal Women with Hypertension: A Prospective, Observational, Pilot Study |
| Selenium | 📋 | ✍ | ⛔ | | 40181943 | Interactive effect between Selenium and Vitamin C levels on risk of hypertension among adult women in the United States: evidence from NHANES 2011 to 2020 |
| Telmisartan | 📋 | | ⛔ | | 39426836 | Efficacy and safety of a novel low-dose triple single-pill combination of telmisartan, amlodipine and indapamide, compared with dual combinations for treatment of hypertension: a randomised, double-blind, active-controlled, international clinical trial |
| Astaxanthin | 📋 | ✍ | ⛔ | | 39586138 | Astaxanthin protects fludrocortisone acetate-induced cardiac injury by attenuating oxidative stress, fibrosis, and inflammation through TGF-β/Smad signaling pathway |
| Cherry | 📋 | | ⛔ | | 36771387 | Dark Sweet Cherry ( Prunus avium) Supplementation Reduced Blood Pressure and Pro-Inflammatory Interferon Gamma (IFNγ) in Obese Adults without Affecting Lipid Profile, Glucose Levels and Liver Enzymes |
| EGCG | 📋 | ✍ | ⛔ | | 40495059 | Cardioprotective and Anti-Hypertensive Effects of Epigallocatechin Gallate: Novel Insights Into Biological Evidence |
| Garlic | 📋 | ✍ | ⛔ | | 39275211 | Garlic and Hypertension: Efficacy, Mechanism of Action, and Clinical Implications |
| Genistein | 📋 | ✍ | ⛔ | | 36690381 | Beneficial effects of the phytoestrogen genistein on hippocampal impairments of spontaneously hypertensive rats (SHR) |
| Ginsenosides | 📋 | ✍ | ⛔ | | 39872289 | Ginsenoside Rg1 improves hypoxia-induced pulmonary vascular endothelial dysfunction through TXNIP/NLRP3 pathway-modulated mitophagy |
| Salidroside | 📋 | | | | 39528930 | PI3K p85α/HIF-1α accelerates the development of pulmonary arterial hypertension by regulating fatty acid uptake and mitophagy |
| Coffee | 📋 | ✍ | ⛔ | | 39368321 | The effects of green coffee bean extract on blood pressure and heart rate: A systematic review and dose-response meta-analysis of randomized controlled trials |
| Ginger | 📋 | ✍ | ⛔ | | 35031435 | The effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials |
| Green Tea | 📋 | ✍ | ⛔ | | 40497293 | Effect of green tea supplementation on blood pressure in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomised controlled trials |
| Orange | 📋 | | ⛔ | | 37469434 | Blood orange juice intake changes specific bacteria of gut microbiota associated with cardiometabolic biomarkers |
| Taurine | 📋 | ✍ | ⛔ | | 40546935 | Taurine ameliorates blood pressure and vascular function in patients with type 2 diabetes: Randomized, double-blind, placebo-controlled trial |
| Allicin | 📋 | ✍ | ⛔ | | 37629140 | Allicin, an Emerging Treatment for Pulmonary Arterial Hypertension: An Experimental Study |
| Apigenin | 📋 | ✍ | ⛔ | | 40416644 | Apigenin Inhibits Cell Ferroptosis by Activating the PI3K/Akt Pathway and Alleviates Renal Injury Caused by Hypertension |
| Crocin | 📋 | ✍ | ⛔ | | 38830933 | Crocin's role in modulating MMP2/TIMP1 and mitigating hypoxia-induced pulmonary hypertension in mice |
| Goji Berry | 📋 | ✍ | ⛔ | | 39021836 | Lycium ruthenicum water extract preserves retinal ganglion cells in chronic ocular hypertension mouse models |
| Hawthorn | 📋 | ✍ | ⛔ | | 38722076 | Study on the hypotensive effect and mechanism of hawthorn (Crataegus pinnatifida) fruits and hyperoside in spontaneously hypertensive rats |
| Nattokinase | 📋 | ✍ | ⛔ | | 39076715 | Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 35345408 | Eucommia ulmoides Oliver- Tribulus terrestris L. Drug Pair Regulates Ferroptosis by Mediating the Neurovascular-Related Ligand-Receptor Interaction Pathway- A Potential Drug Pair for Treatment Hypertension and Prevention Ischemic Stroke |
| Caffeine | 📋 | ✍ | ⛔ | | 40318850 | Preoperative oral caffeine as prophylaxis against post-spinal hypotension in patients undergoing orthopedic lower limb surgery: A randomized, placebo-controlled, double-blinded study |
| Cardamom | 📋 | ✍ | ⛔ | | 38268891 | Effect of cardamom consumption on inflammation and blood pressure in adults: A systematic review and meta-analysis of randomized clinical trials |
| Folate | 📋 | ✍ | ⛔ | | 39590514 | Association between folate deficiency and hypertension: evidence from an observational and Mendelian randomization study |
| Fruits | 📋 | | | | 37915386 | Fruit and vegetable intake and the risk of arterial hypertension in China: A prospective cohort study |
| Medicinal Plants | 📋 | | | | 35892622 | The Effect of Herbal Supplements on Blood Pressure: Systematic Review and Meta-Analysis |
| Naringenin | 📋 | ✍ | ⛔ | | 40573268 | Cardiovascular and Renal Outcomes Following Repeated Naringenin Exposure in Normotensive and Hypertensive Rats |
| Nobiletin | 📋 | ✍ | | | 40581895 | Nobiletin alleviates hypoxia-induced pulmonary hypertension by inhibiting calcium-sensing receptor |
| Olive Oil | 📋 | ✍ | ⛔ | | 33494474 | Extra Virgin Olive Oil Phenols Vasodilate Rat MesentericResistance Artery via Phospholipase C (PLC)-CalciumMicrodomains-Potassium Channels (BK Ca) Signals |
| Polyphenols | 📋 | | | | 35743061 | Novel Insights on Dietary Polyphenols for Prevention in Early-Life Origins of Hypertension: A Review Focusing on Preclinical Animal Models |
| Spirulina | 📋 | ✍ | ⛔ | | 39529406 | The Effect of Spirulina Supplementation on Blood Pressure in Adults: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Clinical Trials |
| Baicalin | 📋 | ✍ | ⛔ | | 38144352 | Baicalin attenuates pulmonary vascular remodeling by inhibiting calpain-1 mediated endothelial-to-mesenchymal transition |
| Cinnamon | 📋 | ✍ | ⛔ | | 39299867 | Effect of cinnamon supplementation on blood pressure, oxidative stress, and inflammatory biomarkers in adults: An umbrella review of the meta-analyses of randomized controlled trials |
| Eucommia | 📋 | ✍ | ⛔ | | 36838952 | The Differences of Mechanisms in Antihypertensive and Anti-Obesity Effects of Eucommia Leaf Extract between Rodents and Humans |
| Fiber | 📋 | ✍ | ⛔ | | 38878601 | Association between preconception dietary fiber intake and hypertensive disorders of pregnancy: The Japan Environment and Children's Study |
| Flavonoids | 📋 | | ⛔ | | 36904184 | Prospective Associations between Cumulative Average Intake of Flavonoids and Hypertension Risk in the CArdioVascular Disease Association Study (CAVAS) |
| Gallic Acid | 📋 | | ⛔ | | 39372584 | The Combination of Gastrodin and Gallic Acid Synergistically Attenuates AngII-Induced Apoptosis and Inflammation via Regulation of Sphingolipid Metabolism |
| Grape | 📋 | | ⛔ | | 32881885 | Grape juice attenuates left ventricular hypertrophy in dyslipidemic mice |
| Graviola | 📋 | ✍ | ⛔ | | 39171117 | Soursop leaf extract and fractions protects against L-NAME-induced hypertension and hyperlipidemia |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 39048980 | Protective effects of the R-(+)-thioctic acid treatment: possible anti-inflammatory activity on heart of hypertensive rats |
| Luteolin | 📋 | ✍ | ⛔ | | 40520031 | Luteolin-Rich Fraction from Dracocephalum lindbergii: Promising Agent for Hypertension Treatment |
| Nitrate | 📋 | ✍ | ⛔ | | 40324575 | Exploring sodium nitrate supplementation in enhancing nitric oxide bioavailability and reducing oxidative stress: implications for blood pressure and endothelial dysfunction in hypertension |
| Oats | 📋 | | ⛔ | | 39599656 | Oat-Protein-Based Diet Lowers Blood Pressure and Prevents Cardiac Remodeling and Dysfunction in Spontaneously Hypertensive Rats |
| Turmeric | 📋 | ✍ | ⛔ | | 35465117 | Effect of Turmeric Supplementation on Blood Pressure and Serum Levels of Sirtuin 1 and Adiponectin in Patients with Nonalcoholic Fatty Liver Disease: A Double-Blind, Randomized, Placebo-Controlled Trial |
| Vitamin E | 📋 | ✍ | ⛔ | | 38296289 | Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis |
| Whey Protein | 📋 | ✍ | ⛔ | | 40471664 | Impacts of Milk Protein Supplementation on Lipid Profile, Blood Pressure, Oxidative Stress, and Liver Enzymes: A Systematic Review and Meta-analysis |
| Almond | 📋 | | ⛔ | | 36331011 | The effect of almond intake on cardiometabolic risk factors, inflammatory markers, and liver enzymes: A systematic review and meta-analysis |
| Black Tea | 📋 | ✍ | ⛔ | | 33237083 | The effect of black tea supplementation on blood pressure: a systematic review and dose-response meta-analysis of randomized controlled trials |
| Coriander | 📋 | | ⛔ | | 36362997 | Evaluation of the Cardiovascular Effects of Coriandrum sativum and Citrus limon to Treat Arsenic-Induced Endothelial Damage and Hypertension in Rats |
| DHEA | 📋 | ✍ | ⛔ | | 36426885 | Simvastatin and Dehydroepiandrosterone Sulfate Effects Against Hypoxic Pulmonary Hypertension Are Not Additive |
| Fish Oil | 📋 | ✍ | ⛔ | | 39423956 | Fish oil supplementation, genetic susceptibility and risk of new-onset hypertension |
| Flaxseed | 📋 | ✍ | ⛔ | | 40520241 | Can flaxseed supplementation alleviate blood pressure in patients with metabolic diseases? Evaluating the strength of evidence using a meta-analysis and GRADE approach |
| Ginseng | 📋 | ✍ | ⛔ | | 40430466 | Exploring Ginseng Bioactive Compound's Role in Hypertension Remedy: An In Silico Approach |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 39917122 | The Combined Effects of Cold Foot Bath and Lavender Oil Inhalation on Autonomic Variables in Healthy Volunteers: A Randomized Controlled Trial |
| Metformin | 📋 | ✍ | ⛔ | | 37055870 | Antihypertensive and antihyperglycemic effects of combinations of losartan with metformin and/or glibenclamide in desoxycorticosterone acetate and streptozotocin-induced hypertensive diabetic rats |
| Probiotics | 📋 | ✍ | ⛔ | | 38472752 | Oral Administration of Fermented Milk from Co-Starter Containing Lactobacillus plantarum Y44 Shows an Ameliorating Effect on Hypertension in Spontaneously Hypertensive Rats |
| Rutin | 📋 | ✍ | ⛔ | | 38126185 | Characterization of PKCα-rutin interactions and their application as a treatment strategy for pulmonary arterial hypertension by inhibiting ferroptosis |
| Saffron | 📋 | ✍ | ⛔ | | 34444896 | The Effect of Saffron Supplementation on Blood Pressure in Adults: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials |
| Sulforaphane | 📋 | ✍ | ⛔ | | 38547510 | Sulforaphane improves redox homeostasis and right ventricular contractility in a model of pulmonary hypertension |
| Tea | 📋 | | | | 39545047 | Effect of tea consumption on the development of hypertension, diabetes, and obesity: a bidirectional two-sample Mendelian randomization analysis |
| Vegetables | 📋 | | | | 37915386 | Fruit and vegetable intake and the risk of arterial hypertension in China: A prospective cohort study |
| Walnut | 📋 | | ⛔ | | 33976753 | Walnut Supplementation Restores the SIRT1-FoxO3a-MnSOD/Catalase Axis in the Heart, Promotes an Anti-Inflammatory Fatty Acid Profile in Plasma, and Lowers Blood Pressure on Fructose-Rich Diet |
| Arctigenin | 📋 | | | | 36359280 | Arctigenin Attenuates Vascular Inflammation Induced by High Salt through TMEM16A/ESM1/VCAM-1 Pathway |
| Argan Oil | 📋 | ✍ | ⛔ | | 27161594 | Beneficial effects of argan oil on blood pressure, insulin resistance, and oxidative stress in rat |
| Baicalein | 📋 | ✍ | ⛔ | | 35806375 | Mechanistic Effects of Baicalein on Aqueous Humor Drainage and Intraocular Pressure |
| Bee Propolis | 📋 | ✍ | ⛔ | | 39846965 | The effect of propolis supplementation on blood pressure: a systematic review and meta-analysis of controlled trials |
| Betaine | 📋 | ✍ | ⛔ | | 39057713 | Oral Supplementation with Betaine Powder Ameliorated High Blood Pressure in Spontaneously Hypertensive Rats |
| Captopril | 📋 | | | | 37735515 | Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice |
| Carotenoids | 📋 | ✍ | ⛔ | | 38219250 | Effect of carotenoid supplementation on blood pressure in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials |
| Carvacrol | 📋 | ✍ | ⛔ | | 37447358 | Carvacrol Improves Vascular Function in Hypertensive Animals by Modulating Endothelial Progenitor Cells |
| Catechins | 📋 | | | | 39272451 | The Potential Mechanisms of Catechins in Tea for Anti-Hypertension: An Integration of Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation |
| Celery | 📋 | | ⛔ | | 38505582 | Antihypertensive Property of Celery: A Narrative Review on Current Knowledge |
| Coconut | 📋 | | ⛔ | | 39221800 | The Effect of Young Coconut Water on Blood Pressure in Hypertensive Patients |
| Dairy | 📋 | | | | 38726444 | The relationship between fermented and nonfermented dairy products consumption and hypertension among premature coronary artery disease patients: Iran premature coronary artery disease study |
| Dihydroquercetin | 📋 | | | | 39456996 | Development and Worsening of Hypertension with Age in Male Wistar Rats as a Physiological Model of Age-Related Hypertension: Correction of Hypertension with Taxifolin |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 35859037 | The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials |
| Formononetin | 📋 | | | | 31922224 | Inhibitory effects of formononetin on the monocrotaline-induced pulmonary arterial hypertension in rats |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 35276465 | Preparation of a new component group of Ginkgo biloba leaves and investigation of the antihypertensive effects in spontaneously hypertensive rats |
| Gotu Kola | 📋 | ✍ | ⛔ | | 34925007 | Centella asiatica (L.) Urb. Prevents Hypertension and Protects the Heart in Chronic Nitric Oxide Deficiency Rat Model |
| Isorhamnetin | 📋 | | | | 39605239 | Bioinformatic Analysis and Molecular Docking Identify Isorhamnetin Is a Candidate Compound in the Treatment of Pulmonary Artery Hypertension |
| Kaempferol | 📋 | ✍ | ⛔ | | 38764667 | Novel Insights in the Hypertension Treatment & Type 2 Diabetics Induced by Angiotensin Receptor Blockers: MD Simulation Studies & Molecular Docking of Some Promising Natural Therapies |
| Lemon | 📋 | | ⛔ | | 37686881 | Antihypertensive and Vasorelaxant Effects of Citric Acid and Lemon Juice in Spontaneously Hypertensive Rats: In Vivo and Ex Vivo Studies |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 38735082 | NADPH and NAC synergistically inhibits chronic ocular hypertension-induced neurodegeneration and neuroinflammation through regulating p38/MAPK pathway and peroxidation |
| Naringin | 📋 | ✍ | ⛔ | | 40548179 | The Alleviative Effect of Naringin Against Cardiovascular Dysfunction and Remodeling in Hypertensive Rats by Suppressing the Angiotensin II Pathway |
| Neferine | 📋 | | | | 40522426 | Vascular Protection of Neferine on Attenuating Angiotensin II-Induced Blood Pressure Elevation by Integrated Network Pharmacology Analysis and RNA-Sequencing Approach |
| Phytochemicals | 📋 | | | | 39313874 | Polyphenol-Mediated Modulation of Non-Coding RNAs: A New Therapeutic Approach for Hypertension - A Review |
| Potassium | 📋 | ✍ | ⛔ | | 38163867 | Effect of low sodium and high potassium diet on lowering blood pressure and cardiovascular events |
| Pumpkin Seed Oil | 📋 | ✍ | ⛔ | | 31445363 | The effects of pumpkin seed oil supplementation on arterial hemodynamics, stiffness and cardiac autonomic function in postmenopausal women |
| Punicalagin | 📋 | ✍ | ⛔ | | 30884808 | Supplementation with Hydroxytyrosol and Punicalagin Improves Early Atherosclerosis Markers Involved in the Asymptomatic Phase of Atherosclerosis in the Adult Population: A Randomized, Placebo-Controlled, Crossover Trial |
| Red Sage | 📋 | ✍ | ⛔ | | 36925635 | Aqueous extract of Salvia miltiorrhiza Bunge reduces blood pressure through inhibiting oxidative stress, inflammation and fibrosis of adventitia in primary hypertension |
| Red Yeast Rice | 📋 | ✍ | ⛔ | | 38812930 | Lipid-lowering, antihypertensive, and antithrombotic effects of nattokinase combined with red yeast rice in patients with stable coronary artery disease: a randomized, double-blinded, placebo-controlled trial |
| Rhodiola | 📋 | ✍ | ⛔ | | 36110120 | The Mechanism of Volatile Oil of Rhodiola tangutica against Hypoxia-Induced Pulmonary Hypertension in Rats Based on RAS Pathway |
| TUDCA | 📋 | ✍ | ⛔ | | 32072406 | Reversal of deleterious effect of hypertension on the liver by inhibition of endoplasmic reticulum stress |
| Wine | 📋 | | ⛔ | | 38521977 | Is coffee, tea, and red wine consumption beneficial for individuals with hypertension? |
| Acai Berry | 📋 | ✍ | ⛔ | | 33661593 | Açaà Reverses Adverse Cardiovascular Remodeling in Renovascular Hypertension: A Comparative Effect With Enalapril |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 33368625 | Role of carnitine in regulation of blood pressure (MAP/SBP) and gene expression of cardiac hypertrophy markers (α/β-MHC) during insulin-induced hypoglycaemia: Role of oxidative stress |
| Angelica | 📋 | ✍ | ⛔ | | 35038707 | Angelica acutiloba Exerts Antihypertensive Effect and Improves Insulin Resistance in Spontaneously Hypertensive Rats Fed with a High-Fat Diet |
| Anthocyanins | 📋 | ✍ | ⛔ | | 33505931 | Protective Effects of Anthocyanin Extract from Purple Sweet Potato ( Ipomoea batatas L.) on Blood MDA Levels, Liver and Renal Activity, and Blood Pressure of Hyperglycemic Rats |
| Antioxidants | 📋 | | ⛔ | | 39261704 | Association between dietary antioxidant indices and hypertension among Chinese adults |
| Apple Polyphenols | 📋 | | ⛔ | | 40382036 | Unripe apple polyphenols extract improves intestinal inflammation and restructures gut microbiota in spontaneously hypertensive rats |
| Asiatic Acid | 📋 | | | | 31254954 | Asiatic acid inhibits cardiac fibrosis throughNrf2/HO-1 and TGF-β1/Smads signaling pathways in spontaneous hypertension rats |
| Asiaticoside | 📋 | | | | 38597444 | [Effect of asiaticoside on systolic blood pressure and relaxation of isolated thoracic aorta of rats] |
| Astragalus Root | 📋 | ✍ | ⛔ | | 38785189 | Hypotension with neurovascular changes and cognitive dysfunction: An epidemiological, pathobiological, and treatment review |
| Barberry | 📋 | ✍ | ⛔ | | 35150818 | The effect of purple-black barberry (Berberis integerrima) on blood pressure in subjects with cardiovascular risk factors: a randomized controlled trial |
| Bilberry | 📋 | ✍ | ⛔ | | 37351191 | A grape seed and bilberry extract reduces blood pressure in individuals at risk of developing type 2 diabetes: the PRECISE study, a double-blind placebo-controlled cross-over intervention study |
| Blackberry | 📋 | | ⛔ | | 40275631 | Nutrigenomic insights and cardiovascular benefits of blackberry (Rubus ulmifolius Schott.) and mugwort (Artemisia campestris L.) |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 33001849 | Caffeic and chlorogenic acids modulate altered activity of key enzymes linked to hypertension in cyclosporine-induced hypertensive rats |
| Capsaicin | 📋 | ✍ | ⛔ | | 38872941 | Capsaicin pretreatment attenuates salt-sensitive hypertension by alleviating AMPK/Akt/Nrf2 pathway in hypothalamic paraventricular nucleus |
| Chamomile | 📋 | ✍ | ⛔ | | 38226236 | A pharmacological and toxicological biochemical study of cardiovascular regulatory effects of hibiscus, corn silk, marjoram, and chamomile |
| Cheese | 📋 | | ⛔ | | 37969456 | Causal relationship association of cheese intake with gestational hypertension and diabetes result from a Mendelian randomization study |
| Chlorella | 📋 | ✍ | ⛔ | | 19811362 | Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 35708145 | Moderation of gut microbiota and bile acid metabolism by chlorogenic acid improves high-fructose-induced salt-sensitive hypertension in mice |
| Choline | 📋 | ✍ | ⛔ | | 36973700 | Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 34690786 | Buddleoside-Rich Chrysanthemum indicum L. Extract has a Beneficial Effect on Metabolic Hypertensive Rats by Inhibiting the Enteric-Origin LPS/TLR4 Pathway |
| Chrysin | 📋 | ✍ | ⛔ | | 32168153 | Chrysin Alleviates Monocrotaline-Induced Pulmonary Hypertension in Rats Through Regulation of Intracellular Calcium Homeostasis in Pulmonary Arterial Smooth Muscle Cells |
| Cinnamaldehyde | 📋 | | | | 40171680 | Cinnamaldehyde alleviates pulmonary hypertension by affecting vascular remodeling through the TLR4/NF-kB/HIF-1a pathway |
| Citicoline | 📋 | ✍ | ⛔ | | 40430513 | Citicoline and Coenzyme Q10: Therapeutic Agents for Glial Activation Reduction in Ocular Hypertension |
| Coconut Oil | 📋 | | ⛔ | | 27618413 | Renoprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 37051424 | Investigating the Role of EPA and DHA on Cellular Oxidative Stress; Profiling Antidiabetic and Antihypertensive Potential |
| Echinacoside | 📋 | | | | 39401152 | Study on the mechanism of echinacoside in preventing and treating hypoxic pulmonary hypertension based on proteomic analyses |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 37051424 | Investigating the Role of EPA and DHA on Cellular Oxidative Stress; Profiling Antidiabetic and Antihypertensive Potential |
| Essential Oils | 📋 | | ⛔ | | 35564590 | Effects of Olfactory Stimulation with Aroma Oils on Psychophysiological Responses of Female Adults |
| Geraniin | 📋 | | | | 37375598 | Geraniin Ameliorates Hypertensive Vascular Remodelling in a Diet-Induced Obese Animal Model through Antioxidant and Anti-Inflammatory Effects |
| Grapefruit extract | 📋 | ✍ | ⛔ | | 30115889 | Moderate Effect of Flavonoids on Vascular and Renal Function in Spontaneously Hypertensive Rats |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 37486473 | Exploration of the molecular mechanism of tea polyphenols against pulmonary hypertension by integrative approach of network pharmacology, molecular docking, and experimental verification |
| Hesperetin | 📋 | | | | 38914702 | Mechanistic study on vasodilatory and antihypertensive effects of hesperetin: ex vivo and in vivo approaches |
| Hydroxytyrosol | 📋 | | | | 32179885 | Maternal Supplementation of Inositols, Fucoxanthin, and Hydroxytyrosol in Pregnant Murine Models of Hypertension |
| Indian Gooseberry | 📋 | | ⛔ | | 32187164 | Preventive Beneficial Effect of an Aqueous Extract of Phyllanthus amarus Schum. and Thonn. (Euphorbiaceae) on DOCA-Salt-Induced Hypertension, Cardiac Hypertrophy and Dysfunction, and Endothelial Dysfunction in Rats |
| Kiwifruit | 📋 | ✍ | ⛔ | | 35807858 | Metabolic and Blood Pressure Effects of Consuming Two Kiwifruit Daily for 7 Weeks: A Randomised Controlled Trial |
| Licorice Root | 📋 | ✍ | ⛔ | | 39519602 | Effects of Licorice Functional Components Intakes on Blood Pressure: A Systematic Review with Meta-Analysis and NETWORK Toxicology |
| Lycopene | 📋 | ✍ | ⛔ | | 35791479 | The inhibitory effects of lycopene and thymoquinone on angiotensin converting enzyme from human plasma (An in vitro study) |
| Mulberry | 📋 | | ⛔ | | 39796483 | Evaluation of the Effects of Mulberry Leaf Extracts Morus alba L. on Cardiovascular, Renal, and Platelet Function in Experimental Arterial Hypertension |
| Myricetin | 📋 | | ⛔ | | 38764667 | Novel Insights in the Hypertension Treatment & Type 2 Diabetics Induced by Angiotensin Receptor Blockers: MD Simulation Studies & Molecular Docking of Some Promising Natural Therapies |
| Nicotinamide | 📋 | ✍ | ⛔ | | 38010699 | Nicotinamide Prevents Retinal Vascular Dropout in a Rat Model of Ocular Hypertension and Supports Ocular Blood Supply in Glaucoma Patients |
| Oleuropein | 📋 | | | | 28347166 | Oleuropein improves glucose tolerance and lipid profile in rats with simultaneous renovascular hypertension and type 2 diabetes |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 33304128 | Profiling the phyto-constituents of Punica granatum fruits peel extract and accessing its in-vitro antioxidant, anti-diabetic, anti-obesity, and angiotensin-converting enzyme inhibitory properties |
| Rapamycin | 📋 | ✍ | | | 36027145 | MTOR INHIBITOR IMPROVES TESTOSTERONE-INDUCED MYOCARDIAL HYPERTROPHY IN HYPERTENSIVE RATS |
| Soy | 📋 | ✍ | ⛔ | | 37225577 | Types of milk consumed and risk of essential hypertension: A 2-sample Mendelian randomization analysis |
| Spikenard | 📋 | ✍ | ⛔ | | 35738117 | Aristolone in Nardostachys jatamansi DC. induces mesenteric vasodilation and ameliorates hypertension via activation of the K ATP channel and PDK1-Akt-eNOS pathway |
| Stevia | 📋 | ✍ | ⛔ | | 35260150 | GlucoMedix®, an extract of Stevia rebaudiana and Uncaria tomentosa, reduces hyperglycemia, hyperlipidemia, and hypertension in rat models without toxicity: a treatment for metabolic syndrome |
| Tea Polyphenols | 📋 | | | | 39857381 | Supplementation with Standardized Green/Black or White Tea Extracts Attenuates Hypertension and Ischemia-Reperfusion-Induced Myocardial Damage in Mice Infused with Angiotensin II |
| Tomato | 📋 | | ⛔ | | 38001046 | Association between tomato consumption and blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 37720374 | Association of vitamin B1 with cardiovascular diseases, all-cause and cardiovascular mortality in US adults |
| Vitamins | 📋 | | | | 38588735 | Effect modification of diet and vitamins on the association between air pollution particles of different diameters and hypertension: A 12-year longitudinal cohort study in densely populated areas of China |
| Wogonin | 📋 | ✍ | ⛔ | | 38942264 | Mechanistic investigation of wogonin in delaying the progression of endothelial mesenchymal transition by targeting the TGF-β1 pathway in pulmonary hypertension |
| Zinc | 📋 | ✍ | ⛔ | | 38581621 | Zinc deficiency induces hypertension by paradoxically amplifying salt sensitivity under high salt intake in mice |
| Acacetin | 📋 | | | | 36520340 | Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose |
| Aloe Vera | 📋 | ✍ | ⛔ | | 33170141 | Evaluation of efficacy of Aloe vera (L.) Burm. f. gel solution in methylcellulose-induced ocular hypertension in New Zealand white rabbits |
| Artichoke | 📋 | ✍ | ⛔ | | 35949557 | Anti-hypertensive Effects of Artichoke Supplementation in Adults: A Systematic Review and Dose-response Meta-analysis of Randomized Controlled Trials |
| Asafoetida | 📋 | ✍ | ⛔ | | 38995276 | Antihypertensive and Antioxidant Effects of an Aqueous Extract of Asafetida in Renovascular Hypertensive Rats |
| Aspirin | 📋 | | ⛔ | | 37470099 | Aspirin delays the onset of hypertensive disorders of pregnancy among nulliparous pregnant women: A secondary analysis of the ASPIRIN trial |
| Avocado | 📋 | ✍ | ⛔ | | 35979778 | Avocado consumption is associated with a reduction in hypertension incidence in Mexican women |
| Avocado Oil | 📋 | | ⛔ | | 34832999 | Avocado Oil Prevents Kidney Injury and Normalizes Renal Vasodilation after Adrenergic Stimulation in Hypertensive Rats: Probable Role of Improvement in Mitochondrial Dysfunction and Oxidative Stress |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 37141519 | [Impact of essential oil vapors inhalation on blood pressure in patients with hypertension] |
| Bergamot | 📋 | ✍ | ⛔ | | 38242036 | The protective effect of Bergamot Polyphenolic Fraction on reno-cardiac damage induced by DOCA-salt and unilateral renal artery ligation in rats |
| Bitter Orange | 📋 | ✍ | ⛔ | | 30115889 | Moderate Effect of Flavonoids on Vascular and Renal Function in Spontaneously Hypertensive Rats |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 28009003 | Acetyl-11-Keto-β-Boswellic Acid Attenuates Prooxidant and Profibrotic Mechanisms Involving Transforming Growth Factor-β1, and Improves Vascular Remodeling in Spontaneously Hypertensive Rats |
| Butyrate | 📋 | | ⛔ | | 38176636 | Sodium butyrate alleviates right ventricular hypertrophy in pulmonary arterial hypertension by inhibiting H19 and affecting the activation of let-7g-5p/IGF1 receptor/ERK |
| Calcium | 📋 | ✍ | ⛔ | | 39534319 | Blood Pressure Decreases in Overweight Elderly Individuals on Vitamin D: A Randomized Trial |
| Carnosic Acid | 📋 | | | | 39181360 | Carnosic acid, a novel food-source AT1R antagonist and its anti-hypertension mechanism |
| Casein Protein | 📋 | ✍ | ⛔ | | 40471664 | Impacts of Milk Protein Supplementation on Lipid Profile, Blood Pressure, Oxidative Stress, and Liver Enzymes: A Systematic Review and Meta-analysis |
| Cat's Claw | 📋 | ✍ | ⛔ | | 35260150 | GlucoMedix®, an extract of Stevia rebaudiana and Uncaria tomentosa, reduces hyperglycemia, hyperlipidemia, and hypertension in rat models without toxicity: a treatment for metabolic syndrome |
| Cordycepin | 📋 | | | | 38816406 | Mechanisms of cordycepin in the treatment of pulmonary arterial hypertension in rats based on metabonomics and transcriptomics |
| Cordyceps | 📋 | ✍ | ⛔ | | 36143487 | Cordyceps militaris Inhibited Angiotensin-Converting Enzyme through Molecular Interaction between Cordycepin and ACE C-Domain |
| Cornus | 📋 | | | | 39022064 | Drug pair of Cornus officinalis and Radix achyranthis bidentatae improves renal injury of hypertension by regulating metabolic reprogramming mediated by eNOS |
| Cranberry | 📋 | ✍ | ⛔ | | 32535781 | Effects of chronic consumption of specific fruit (berries, citrus and cherries) on CVD risk factors: a systematic review and meta-analysis of randomised controlled trials |
| Cucumber | 📋 | | ⛔ | | 38162466 | Cucumber ( Cucumis sativus L.) Fruit and Combination with Losartan Attenuate the Elevation of Blood Pressure in Hypertensive Rats Induced by Angiotensin II |
| D-Ribose | 📋 | ✍ | ⛔ | | 17604325 | Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats |
| Dihydroartemisinin | 📋 | | | | 35862468 | Dihydroartemisinin Attenuates Hypoxic Pulmonary Hypertension via the Downregulation of miR-335 Targeting Vangl2 |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 39461017 | Dihydromyricetin treats pulmonary hypertension by modulating CKLF1/CCR5 axis-induced pulmonary vascular cell pyroptosis |
| Diosmetin | 📋 | | | | 36015099 | Investigation into the Antihypertensive Effects of Diosmetin and Its Underlying Vascular Mechanisms Using Rat Model |
| Eggplant | 📋 | | ⛔ | | 36985807 | Evaluation of the Antihypertensive Activity of Eggplant Acetylcholine and γ-Aminobutyric Acid in Spontaneously Hypertensive Rats |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 36233611 | Ellagic Acid Effect on the Components of Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| Eucalyptol | 📋 | | | | 37886137 | Effect of eucalyptol on matrix metalloproteinase-9 and its tissue inhibitor in hypertensive rats |
| Eugenol | 📋 | | | | 40261349 | The antihypertensive effect of the coadministration of exercise and eugenol in deoxycorticosterone acetate-induced hypertension in rats |
| Fenugreek | 📋 | ✍ | ⛔ | | 36763260 | The Effects of Fenugreek Seed Consumption on Blood Pressure: A Systematic Review and Meta-analysis of Randomized Controlled Trials |
| Flavones | 📋 | | | | 38630898 | The association between flavonoids intake and hypertension in U.S. adults: A cross-sectional study from The National Health and Nutrition Examination Survey |
| Fucoidan | 📋 | ✍ | ⛔ | | 30557519 | Evidence for the Fucoidan/P-Selectin Axis as a Therapeutic Target in Hypoxia-induced Pulmonary Hypertension |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 40513841 | Fucoxanthin Ameliorates Vascular Remodeling via Attenuating Oxidative Stress in Hypoxic Pulmonary Hypertension Rats |
| GABA | 📋 | ✍ | ⛔ | | 28911464 | Effect of γ-aminobutyric acid and nattokinase-enriched fermented beans on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats |
| Galangal | 📋 | ✍ | ⛔ | | 35566064 | Vasodilatory Effect of Alpinia officinarum Extract in Rat Mesenteric Arteries |
| Galangin | 📋 | | | | 35687907 | Cardiorenal dysfunction and hypertrophy induced by renal artery occlusion are normalized by galangin treatment in rats |
| Ginger extract | 📋 | ✍ | ⛔ | | 35039142 | Cardiometabolic effects of Zingiber Officinale Roscoe extracts in Type 2 diabetic Cameroonians patients after six weeks of add-on Therapy : A single clinical-arm trial |
| Grapefruit | 📋 | | ⛔ | | 32520418 | Grapefruit juice enhances the systolic blood pressure-lowering effects of dietary nitrate-containing beetroot juice |
| Guava | 📋 | | ⛔ | | 36271572 | Effects of Psidium guajava L. leaves extract on blood pressure control and IL-10 production in salt-dependent hypertensive rats |
| Honokiol | 📋 | | | | 35684335 | The Modulation of Arachidonic Acid Metabolism and Blood Pressure-Lowering Effect of Honokiol in Spontaneously Hypertensive Rats |
| Icariin | 📋 | ✍ | | | 33359002 | Sex hormone-like Effects of Icariin on T-cells immune modulation in spontaneously hypertensive rats |
| Inulin | 📋 | ✍ | ⛔ | | 36148807 | Inulin intake and the incidence of cardiometabolic diseases: a prospective cohort study |
| Irisin | 📋 | | | | 40560058 | Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin-Mediated Regulation of ENO1 |
| Kudzu Root | 📋 | ✍ | ⛔ | | 33155599 | Puerarin induces mouse mesenteric vasodilation and ameliorates hypertension involving endothelial TRPV4 channels |
| L-Carnitine | 📋 | ✍ | ⛔ | | 35911183 | l-Carnitine therapy improves right heart dysfunction through Cpt1-dependent fatty acid oxidation |
| L-Theanine | 📋 | ✍ | ⛔ | | 34822436 | l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat |
| Lactobacillus plantarum | 📋 | | ⛔ | | 27144579 | Effects of Lactobacillus plantarum TWK10-Fermented Soymilk on Deoxycorticosterone Acetate-Salt-Induced Hypertension and Associated Dementia in Rats |
| Lemon Balm | 📋 | ✍ | ⛔ | | 34766389 | Effect of Melissa officinalis on systolic and diastolic blood pressures in essential hypertension: A double-blind crossover clinical trial |
| Lemon Verbena | 📋 | | ⛔ | | 33810049 | A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of a Polyphenolic Extract ( Hibiscus sabdariffa and Lippia citriodora) for Reducing Blood Pressure in Prehypertensive and Type 1 Hypertensive Subjects |
| Lemongrass | 📋 | ✍ | ⛔ | | 36290288 | Exploring the Anti-Hypertensive Potential of Lemongrass-A Comprehensive Review |
| Lutein | 📋 | ✍ | ⛔ | | 31356404 | Association Between Dietary Carotenoid Intakes and Hypertension in Adults: National Health and Nutrition Examination Survey 2007-2014 |
| Magnolol | 📋 | | | | 35658230 | Magnolol alleviates hypoxia-induced pulmonary vascular remodeling through inhibition of phenotypic transformation in pulmonary arterial smooth muscle cells |
| Maitake Mushrooms | 📋 | | ⛔ | | 31139649 | Structural Elucidation and Immune-Enhancing Effects of Novel Polysaccharide from Grifola frondosa |
| Mangiferin | 📋 | | ⛔ | | 38094010 | Mangiferin alleviates renal inflammatory injury in spontaneously hypertensive rats by inhibiting MCP-1/CCR2 signaling pathway |
| Mangosteen | 📋 | ✍ | ⛔ | | 39006850 | α-Mangostin reduces hypertension in spontaneously hypertensive rats and inhibits EMT and fibrosis in Ang II-induced HK-2 cells |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 28858976 | Galectin-3 pharmacological inhibition attenuates early renal damage in spontaneously hypertensive rats |
| Myrtle | 📋 | ✍ | ⛔ | | 33475094 | Myrtus communis improves cognitive impairment in renovascular hypertensive rats |
| NMN | 📋 | ✍ | ⛔ | | 37718359 | NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension |
| Nuts | 📋 | | ⛔ | | 35118090 | Protective Effects of Appropriate Amount of Nuts Intake on Childhood Blood Pressure Level: A Cross-Sectional Study |
| Olive | 📋 | ✍ | ⛔ | | 36861461 | Dietary intake of table olives exerts antihypertensive effects in association with changes in gut microbiota in spontaneously hypertensive rats |
| Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 40089708 | Omega-6 polyunsaturated fatty acids and their metabolites: a potential targeted therapy for pulmonary hypertension |
| Onion | 📋 | ✍ | ⛔ | | 39203947 | LDL-Cholesterol-Lowering Effects of a Dietary Supplement Containing Onion and Garlic Extract Used in Healthy Volunteers |
| Oolong Tea | 📋 | | ⛔ | | 35600813 | Green and Oolong Tea Extracts With Different Phytochemical Compositions Prevent Hypertension and Modulate the Intestinal Flora in a High-Salt Diet Fed Wistar Rats |
| Paeoniflorin | 📋 | | | | 35582418 | Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing TAK1-MAPK/NF-κB pathways |
| Panax Notoginseng | 📋 | ✍ | ⛔ | | 37583037 | [Panax notoginseng saponins improve monocrotaline-induced pulmonary arterial hypertension in rats by inhibiting ADAM10/Notch3 signaling pathway] |
| Piperine | 📋 | ✍ | ⛔ | | 32746709 | Chemical constituents from the fruits of Piper longum L. and their vascular relaxation effect on rat mesenteric arteries |
| Pistachio | 📋 | ✍ | ⛔ | | 38881209 | Evaluation of the Effect of Pistacia atlantica Oleoresin on Blood Sugar, Pressure and Lipids in Patients With Type 2 Diabetes: A Single-Blind, Placebo-Controlled Trial |
| Progesterone | 📋 | ✍ | ⛔ | | 36848943 | Serum Progesterone is Negatively Associated with Hypertension and Blood Pressure Indicators Among Men and Postmenopausal Women |
| Protein | 📋 | ✍ | ⛔ | | 39001774 | Effect of Relative Protein Intake on Hypertension and Mediating Role of Physical Fitness and Circulating Fatty Acids: A Mendelian Randomization Study |
| Psyllium | 📋 | ✍ | ⛔ | | 39479650 | The effect of psyllium consumption on blood pressure: Systematic review and dose-response meta-analysis of randomized controlled trials |
| Pu-erh Tea | 📋 | ✍ | ⛔ | | 39654443 | Based on LC-MS and network pharmacology, the quality components, and anti-hypertensive mechanisms of three types of tea were studied |
| PUFA | 📋 | | | | 37753192 | Association of dietary fatty acid intake with hypertension in children and adolescents: evidence from the NHANES 2005-2018 |
| Quinoa | 📋 | | ⛔ | | 37476690 | Glucolipid metabolism improvement in impaired glucose tolerance subjects consuming a Quinoa-based diet: a randomized parallel clinical trial |
| Rapeseed Oil | 📋 | ✍ | | | 35596008 | The effects of sesame, canola, and sesame-canola oils on cardiometabolic markers in patients with type 2 diabetes: a triple-blind three-way randomized crossover clinical trial |
| Raspberry | 📋 | ✍ | ⛔ | | 38628181 | The effects of raspberry consumption on lipid profile and blood pressure in adults: A systematic review and meta-analysis |
| Safflower | 📋 | ✍ | ⛔ | | 39155275 | Safflower Alleviates Pulmonary Arterial Hypertension by Inactivating NLRP3: A Combined Approach of Network Pharmacology and Experimental Verification |
| Salt | 📋 | | ⛔ | | 35788204 | Role of no table salt on hypertension and stroke based on large sample size from National Health and Nutrition Examination Survey database |
| Salvianolic Acid | 📋 | | | | 36121714 | Salvianolic Acid Ameliorates Pressure Overload-Induced Cardiac Endothelial Dysfunction via Activating HIF1[Formula: see text]/HSF1/CD31 Pathway |
| Sesame | 📋 | ✍ | ⛔ | | 39721700 | Antihypertensive and Angiotensin I-Converting Enzyme-Inhibitory Effects of the Leaves of Sesamum indicum and Bioactive Compounds |
| Silibinin | 📋 | ✍ | | | 38789021 | Silibinin attenuates TGF-β2-induced fibrogenic changes in human trabecular meshwork cells by targeting JAK2/STAT3 and PI3K/AKT signaling pathways |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 38454401 | Effect of soy isoflavone supplementation on blood pressure: a meta-analysis of randomized controlled trials |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 30097121 | Urtica dioica L. leaf extract modulates blood pressure and oxidative stress in spontaneously hypertensive rats |
| Tangeretin | 📋 | | | | 32479886 | Tangeretin ameliorates erectile and testicular dysfunction in a rat model of hypertension |
| Theobromine | 📋 | ✍ | ⛔ | | 25750625 | The relevance of theobromine for the beneficial effects of cocoa consumption |
| Thymoquinone | 📋 | | ⛔ | | 35791479 | The inhibitory effects of lycopene and thymoquinone on angiotensin converting enzyme from human plasma (An in vitro study) |
| Valerian Root | 📋 | ✍ | ⛔ | | 33006866 | Valeriana officinalis extract and 7-Nitroindozole ameliorated seizure behaviours, and 7-Nitroindozole reduced blood pressure and ECG parameters in pentylenetetrazole-kindled rats |
| Vitamin A | 📋 | ✍ | ⛔ | | 39803286 | Association of Dietary Intake of Vitamin A With Adolescent Hypertension: A Cross-Sectional Study Based on NHANES 1999-2018 |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 33131313 | Inverse Association Between Riboflavin Intake and New-Onset Hypertension: A Nationwide Cohort Study in China |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 33718421 | Network and 16S rRNA Sequencing-Combined Approach Provides Insightal Evidence of Vitamin K 2 for Salt-Sensitive Hypertension |
| Yiang Yiang Essential Oil | 📋 | | ⛔ | | 38087747 | Effect of Lavandula angustifolia and Cananga odorata on decrease of blood pressure in high blood pressure volunteers: A randomized controlled trial |
| 5-HTP | 📋 | ✍ | ⛔ | | 26781281 | Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 19491530 | Dietary Alpha-Linolenic Acid Inhibits Angiotensin-Converting Enzyme Activity and mRNA Expression Levels in the Aorta of Spontaneously Hypertensive Rats |
| Amaranth | 📋 | | ⛔ | | 33101347 | Amaranth as a Source of Antihypertensive Peptides |
| Andrographolide | 📋 | | | | 36543019 | Andrographolide improves the dysfunction of endothelial progenitor cells from angiotensin II-induced hypertensive mice through SIRT1 signaling |
| Anethole | 📋 | | | | 29567537 | Trans-anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats |
| Anise | 📋 | ✍ | ⛔ | | 30904702 | Preclinical investigation of the cardiovascular actions induced by aqueous extract of Pimpinella anisum L. seeds in rats |
| Apple | 📋 | | ⛔ | | 35499960 | Associations between fruit consumption and home blood pressure in a randomly selected sample of the general Swedish population |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 36152934 | Dose-dependent effect of vinegar on blood pressure: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials |
| Apricot | 📋 | | ⛔ | | 35702770 | Antihypertensive Activity of Prunus armeniaca in Hypertensive Rats |
| Arjuna | 📋 | ✍ | ⛔ | | 27401289 | Beneficial effects of aqueous extract of stem bark of Terminalia arjuna (Roxb.), An ayurvedic drug in experimental pulmonary hypertension |
| Artemisinin | 📋 | | | | 35757500 | Artemisinin and Its Derivate Alleviate Pulmonary Hypertension and Vasoconstriction in Rodent Models |
| Atractylodes | 📋 | ✍ | ⛔ | | 40446979 | Polysaccharide of Atractylodes macrocephala Koidz alleviated fructose-induced salt-sensitive hypertension and renal injury via suppressing SIRT1/Nlrp3/caspase-1 pathway in mice |
| Basil | 📋 | ✍ | ⛔ | | 37064472 | Phytochemical characterization, antioxidant activity and antihypertensive evaluation of Ocimum basilicum L. in l-NAME induced hypertensive rats and its correlation analysis |
| Bay Leaf | 📋 | | ⛔ | | 35549860 | Study of the Antihypertensive Effect of Laurus nobilis in Rats |
| BCAA | 📋 | ✍ | ⛔ | | 40548406 | Effects of Dietary BCAAs Intake on the Blood Pressure in Dahl Salt-Sensitive Rats |
| Bee Venom | 📋 | ✍ | ⛔ | | 36456799 | Apitherapy combination improvement of blood pressure, cardiovascular protection, and antioxidant and anti-inflammatory responses in dexamethasone model hypertensive rats |
| Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 30847114 | Efficacy of bergamot: From anti-inflammatory and anti-oxidative mechanisms to clinical applications as preventive agent for cardiovascular morbidity, skin diseases, and mood alterations |
| Berries | 📋 | | | | 26227795 | Polyphenol-rich juices reduce blood pressure measures in a randomised controlled trial in high normal and hypertensive volunteers |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 31356404 | Association Between Dietary Carotenoid Intakes and Hypertension in Adults: National Health and Nutrition Examination Survey 2007-2014 |
| Beta-Cryptoxanthin | 📋 | | | | 31356404 | Association Between Dietary Carotenoid Intakes and Hypertension in Adults: National Health and Nutrition Examination Survey 2007-2014 |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 37513599 | Oat Beta-Glucan Alone and in Combination with Hydrochlorothiazide Lowers High Blood Pressure in Male but Not Female Spontaneously Hypertensive Rats |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 39265206 | β-sitosterol alleviates pulmonary arterial hypertension by altering smooth muscle cell phenotype and DNA damage/cGAS/STING signaling |
| Bitter Melon | 📋 | ✍ | ⛔ | | 35705768 | Momordica charantia Extract Confers Protection Against Hypertension in Dahl Salt-Sensitive Rats |
| Bok Choy | 📋 | | ⛔ | | 36249822 | Antihypertensive potential of Brassica rapa leaves: An in vitro and in silico approach |
| Brazil Nut | 📋 | | ⛔ | | 34156903 | Impact of Brazil Nut ( Bertholletia excelsa, H.B.K.) Supplementation on Body Composition, Blood Pressure, and the Vascular Reactivity of Wistar Rats When Submitted to a Hypersodium Diet |
| Bread | 📋 | | | | 36366944 | The impact of low-salt bread as a simple diet on hypertensive patients with cardiovascular comorbidities |
| Camphor | 📋 | ✍ | ⛔ | | 31255877 | The combination of hawthorn extract and camphor significantly increases blood pressure: A meta-analysis and systematic review |
| CAPE | 📋 | | | | 28833317 | Effects of Propolis, Caffeic Acid Phenethyl Ester, and Pollen on Renal Injury in Hypertensive Rat: An Experimental and Theoretical Approach |
| Carbohydrates | 📋 | | | | 36364706 | Greater Protection of Lower Dietary Carbohydrate to Fiber Ratio (CFR) against Poor Blood Pressure Control in Patients with Essential Hypertension: A Cross-Sectional Study |
| Carrot | 📋 | | ⛔ | | 26644239 | Fruit and Vegetable Consumption and the Incidence of Hypertension in Three Prospective Cohort Studies |
| Cashew | 📋 | | ⛔ | | 36578402 | Antihypertensive activity of roasted cashew nut in mixed petroleum fractions-induced hypertension: An in vivo and in silico approaches |
| Chromium | 📋 | ✍ | ⛔ | | 34237387 | Effects of chromium supplementation on blood pressure, body mass index, liver function enzymes and malondialdehyde in patients with type 2 diabetes: A systematic review and dose-response meta-analysis of randomized controlled trials |
| Cinnamic Acid | 📋 | | | | 39752866 | Cinnamic acid lowers blood pressure and reverses vascular endothelial dysfunction in rats |
| Citrus Fruits | 📋 | | ⛔ | | 35499960 | Associations between fruit consumption and home blood pressure in a randomly selected sample of the general Swedish population |
| Clary Sage Essential Oil | 📋 | ✍ | ⛔ | | 37141519 | [Impact of essential oil vapors inhalation on blood pressure in patients with hypertension] |
| Clove | 📋 | | ⛔ | | 15856420 | Enhanced hypotensive effects of the essential oil of Ocimum gratissimum leaves and its main constituent, eugenol, in DOCA-salt hypertensive conscious rats |
| Clove Essential Oil | 📋 | | ⛔ | | 37141519 | [Impact of essential oil vapors inhalation on blood pressure in patients with hypertension] |
| Coptis Chinensis | 📋 | | ⛔ | | 34554677 | Bioactive Compounds From Coptidis Rhizoma Alleviate Pulmonary Arterial Hypertension by Inhibiting Pulmonary Artery Smooth Muscle Cells' Proliferation and Migration |
| Coriander Essential Oil | 📋 | ✍ | ⛔ | | 37141519 | [Impact of essential oil vapors inhalation on blood pressure in patients with hypertension] |
| Corn | 📋 | | ⛔ | | 38814365 | Associations between whole grains intake and new-onset hypertension: a prospective cohort study |
| Corn Silk | 📋 | ✍ | ⛔ | | 38226236 | A pharmacological and toxicological biochemical study of cardiovascular regulatory effects of hibiscus, corn silk, marjoram, and chamomile |
| Crocetin | 📋 | | | | 25531977 | Crocetin, a carotenoid derived from saffron (Crocus sativus L.), improves acetylcholine-induced vascular relaxation in hypertension |
| Cyanidin | 📋 | ✍ | | | 33760143 | Cyanidin-3-O-β-glucoside protects against pulmonary artery hypertension induced by monocrotaline via the TGF-β1/p38 MAPK/CREB signaling pathway |
| D-Limonene | 📋 | ✍ | ⛔ | | 39699454 | In Vivo Anti-Inflammatory Activity of D-Limonene in a Rat Model of Monocrotaline-Induced Pulmonary Hypertension: Implications to the Heart Function |
| Daidzein | 📋 | ✍ | ⛔ | | 33899670 | Dietary isoflavones intake is inversely associated with non-alcoholic fatty liver disease, hyperlipidaemia and hypertension |
| Diosgenin | 📋 | | | | 35997017 | Diosgenin exerts an antihypertensive effect in spontaneously hypertensive rats via gut-brain communication |
| Diosmin | 📋 | ✍ | ⛔ | | 22266490 | Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats |
| Echinacea | 📋 | ✍ | ⛔ | | 28061036 | Antioxidant, Antidiabetic, and Antihypertensive Properties of Echinacea Purpurea Flower Extract and Caffeic Acid Derivatives Using In Vitro Models |
| Eclipta Alba | 📋 | ✍ | | | 34627325 | A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model |
| Egg | 📋 | | ⛔ | | 31950113 | Enzymatic Hydrolysis of Egg White Protein Exerts a Hypotensive Effect in Spontaneously Hypertensive Rats |
| Elderberry | 📋 | ✍ | ⛔ | | 27417664 | The beneficial effects on blood pressure, dyslipidemia and oxidative stress of Sambucus nigra extract associated with renin inhibitors |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 21499116 | Effect of evening primrose oil and ω-3 polyunsaturated fatty acids on the cardiovascular risk of celecoxib in rats |
| Fat | 📋 | | | | 37461334 | Effect of lard plus soybean oil on blood pressure and other cardiometabolic risk factors in healthy subjects: a randomized controlled-feeding trial |
| Fatty Acids | 📋 | | | | 38036572 | A prospective cohort study on the association between dietary fatty acids intake and risk of hypertension incident |
| Fig | 📋 | | ⛔ | | 28187689 | Evaluation of antihypertensive potential of Ficus carica fruit |
| Fisetin | 📋 | ✍ | ⛔ | | 30668312 | Protective effect of Fisetin against angiotensin II-induced apoptosis by activation of IGF-IR-PI3K-Akt signaling in H9c2 cells and spontaneous hypertension rats |
| Forskolin | 📋 | ✍ | ⛔ | | 32340314 | A Dietary Combination of Forskolin with Homotaurine, Spearmint and B Vitamins Protects Injured Retinal Ganglion Cells in a Rodent Model of Hypertensive Glaucoma |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 33534427 | Is there a beneficial effect of gamma-linolenic acid supplementation on body fat in postmenopausal hypertensive women? A prospective randomized double-blind placebo-controlled trial |
| Garlic Oil | 📋 | | ⛔ | | 36364887 | Perinatal Garlic Oil Supplementation Averts Rat Offspring Hypertension Programmed by Maternal Chronic Kidney Disease |
| Geniposide | 📋 | | | | 32830328 | Geniposide in Gardenia jasminoides var. radicans Makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors |
| Gingerol | 📋 | ✍ | | | 30643517 | 6-Gingerol Normalizes the Expression of Biomarkers Related to Hypertension via PPAR δ in HUVECs, HEK293, and Differentiated 3T3-L1 Cells |
| Ginkgolides | 📋 | | | | 31739841 | Ginkgolide A protects adverse cardiac remodeling through enhancing antioxidation and nitric oxide utilization in mice with pressure overload |
| Glucosamine | 📋 | ✍ | ⛔ | | 39596173 | Plasma Glutaminyl-Peptide Cyclotransferase Mediates Glucosamine-Metabolism-Driven Protection Against Hypertension: A Mendelian Randomization Study |
| Glycine | 📋 | ✍ | ⛔ | | 36307799 | The causal associations of circulating amino acids with blood pressure: a Mendelian randomization study |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 39519602 | Effects of Licorice Functional Components Intakes on Blood Pressure: A Systematic Review with Meta-Analysis and NETWORK Toxicology |
| Hemp Oil | 📋 | ✍ | ⛔ | | 40076524 | Cannabis sativa L. Leaf Oil Displays Cardiovascular Protective Effects in Hypertensive Rats |
| Holy Basil | 📋 | ✍ | ⛔ | | 29673152 | Beneficial Effect of Ocimum sanctum (Linn) Against Monocrotaline-Induced Pulmonary Hypertension in Rats |
| Horsetail Grass | 📋 | ✍ | ⛔ | | 35168030 | Antihypertensive effect of Equisetum arvense L.: a double-blind, randomized efficacy and safety clinical trial |
| Hyperoside | 📋 | | | | 38722076 | Study on the hypotensive effect and mechanism of hawthorn (Crataegus pinnatifida) fruits and hyperoside in spontaneously hypertensive rats |
| Iron | 📋 | ✍ | ⛔ | | 36771298 | Targeting Iron Metabolism and Ferroptosis as Novel Therapeutic Approaches in Cardiovascular Diseases |
| Isoflavones | 📋 | ✍ | ⛔ | | 33445531 | The Vascular Effects of Isolated Isoflavones-A Focus on the Determinants of Blood Pressure Regulation |
| Krill Oil | 📋 | ✍ | ⛔ | | 27292941 | Effects of long-term intake of Antarctic krill oils on artery blood pressure in spontaneously hypertensive rats |
| L-Glutamine | 📋 | ✍ | ⛔ | | 36458162 | The association of dietary glutamine supplementation with the development of high salt-induced hypertension in rats |
| L-Histidine | 📋 | ✍ | ⛔ | | 33513395 | Protective effect of oral histidine on hypertension in Dahl salt-sensitive rats induced by high-salt diet |
| L-Lysine | 📋 | ✍ | ⛔ | | 38639736 | Lysine and salt-sensitive hypertension |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 33218054 | Developmental Programming and Reprogramming of Hypertension and Kidney Disease: Impact of Tryptophan Metabolism |
| Laminaria | 📋 | ✍ | ⛔ | | 40390848 | Effects of Daily Kombu (Laminaria japonica) Intake on Body Composition, Blood Pressure, and Fecal Microbiota in Healthy Adult Japanese: A Randomized, Double-Blind Study |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 21157172 | [Effects of aromatherapy on changes in the autonomic nervous system, aortic pulse wave velocity and aortic augmentation index in patients with essential hypertension] |
| Lettuce | 📋 | | ⛔ | | 35871120 | Double-blind controlled dietary cross-over intervention with differentially fertilised intact lettuce leaves shows acute reduction in blood pressure in young adults, associated with faster uptake of nitrate than of phenolics |
| Ligustilide | 📋 | | | | 31762036 | Ligustilide Inhibited Rat Vascular Smooth Muscle Cells Migration via c-Myc/MMP2 and ROCK/JNK Signaling Pathway |
| Limonin | 📋 | | | | 37290669 | Limonin ameliorates cardiovascular dysfunction and remodeling in hypertensive rats |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 36939291 | Association of omega-6 polyunsaturated fatty acids with blood pressure: A systematic review and meta-analysis of observational studies |
| Lychee | 📋 | | ⛔ | | 33470120 | Polyphenol-Rich Extract from Litchi chinensis Seeds Alleviates Hypertension-Induced Renal Damage in Rats |
| Maca Root | 📋 | ✍ | ⛔ | | 24931003 | Maca reduces blood pressure and depression, in a pilot study in postmenopausal women |
| Magnolia | 📋 | ✍ | ⛔ | | 35308213 | Vasorelaxant Activities and its Underlying Mechanisms of Magnolia Volatile Oil on Rat Thoracic Aorta Based on Network Pharmacology |
| Mango | 📋 | | ⛔ | | 35506190 | Changes in systolic blood pressure, postprandial glucose, and gut microbial composition following mango consumption in individuals with overweight and obesity |
| Mango Leaf | 📋 | | ⛔ | | 25724882 | Phytochemical and in vitro and in vivo biological investigation on the antihypertensive activity of mango leaves (Mangifera indica L.) |
| Marjoram | 📋 | | ⛔ | | 38226236 | A pharmacological and toxicological biochemical study of cardiovascular regulatory effects of hibiscus, corn silk, marjoram, and chamomile |
| Mastic | 📋 | ✍ | ⛔ | | 38999899 | Antihypertensive Potential of Pistacia lentiscus var. Chia: Molecular Insights and Therapeutic Implications |
| Millet | 📋 | | | | 38814365 | Associations between whole grains intake and new-onset hypertension: a prospective cohort study |
| Minerals | 📋 | | | | 37836507 | Vitamins and Minerals for Blood Pressure Reduction in the General, Normotensive Population: A Systematic Review and Meta-Analysis of Six Supplements |
| MSM | 📋 | ✍ | ⛔ | | 23118745 | Protective effects of methylsulfonylmethane on hemodynamics and oxidative stress in monocrotaline-induced pulmonary hypertensive rats |
| Mucuna Pruriens | 📋 | ✍ | ⛔ | | 39575208 | Effect of bioactive compounds of Mucuna pruriens on proteins of Wnt/β-catenin pathway in pulmonary hypertension by in silico approach |
| Mugwort | 📋 | | ⛔ | | 40275631 | Nutrigenomic insights and cardiovascular benefits of blackberry (Rubus ulmifolius Schott.) and mugwort (Artemisia campestris L.) |
| Mushrooms | 📋 | | ⛔ | | 37157920 | Edible mushrooms as potential functional foods in amelioration of hypertension |
| NAD | 📋 | | | | 37718359 | NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension |
| Neohesperidin | 📋 | | | | 35677431 | Neohesperidin Protects Angiotensin II-Induced Hypertension and Vascular Remodeling |
| Oak Bark | 📋 | ✍ | ⛔ | | 22105311 | Cardioprotective and hepatoprotective effects of ellagitannins from European oak bark (Quercus petraea L.) extract in rats |
| Paeonol | 📋 | | | | 36855263 | Paeonol improves renal and vascular angiotensin II type 1 receptor function via inhibiting oxidative stress in spontaneously hypertensive rats |
| Parthenolide | 📋 | | | | 39265445 | Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling |
| Patchouli | 📋 | ✍ | ⛔ | | 37177974 | Patchouli alcohol against renal fibrosis of spontaneously hypertensive rats via Ras/Raf-1/ERK1/2 signalling pathway |
| PEA | 📋 | ✍ | ⛔ | | 38269580 | Evaluation of the nutraceutical Palmitoylethanolamide in reducing intraocular pressure (IOP) in patients with glaucoma or ocular hypertension: a systematic review and meta-analysis |
| Pear | 📋 | | ⛔ | | 35499960 | Associations between fruit consumption and home blood pressure in a randomly selected sample of the general Swedish population |
| Persimmon | 📋 | | ⛔ | | 31652855 | The Intraocular Pressure-Lowering Effect of Persimmon leaves ( Diospyros kaki) in a Mouse Model of Glaucoma |
| Plum | 📋 | | ⛔ | | 29241576 | Anthocyanin-rich plum juice reduces ambulatory blood pressure but not acute cognitive function in younger and older adults: a pilot crossover dose-timing study |
| Polydatin | 📋 | ✍ | | | 35370672 | Polydatin Glycosides Improve Monocrotaline-Induced Pulmonary Hypertension Injury by Inhibiting Endothelial-To-Mesenchymal Transition |
| PQQ | 📋 | ✍ | ⛔ | | 36030026 | Pyrroloquinoline quinone (PQQ) improves pulmonary hypertension by regulating mitochondrial and metabolic functions |
| Proanthocyanidins | 📋 | | | | 36226711 | Bioactivities and mechanisms of dietary proanthocyanidins on blood pressure lowering: A critical review of in vivo and clinical studies |
| Procyanidins | 📋 | | ⛔ | | 29119920 | Polyphenols: Inflammation |
| Pterostilbene | 📋 | ✍ | ⛔ | | 38573589 | EFFECTS OF PTEROSTILBENE ON HEART AND LUNG OXIDATIVE STRESS PARAMETERS IN TWO EXPERIMENTAL MODELS OF CARDIOVASCULAR DISEASE: MYOCARDIAL INFARCTION AND PULMONARY ARTERIAL HYPERTENSION |
| Pyridoxal-5-Phosphate | 📋 | ✍ | ⛔ | | 39385670 | Pyridoxal-5'-phosphate: A cost-effective treatment candidate for hypertensive patients? |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 33177919 | Novel Antihypertension Mechanism of β-Glucan by Corin and ANP-Mediated Natriuresis in Mice |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 37141519 | [Impact of essential oil vapors inhalation on blood pressure in patients with hypertension] |
| Rosmarinic Acid | 📋 | ✍ | | | 38151743 | The Role of Rosmarinic Acid in the Protection against Inflammatory Factors in Rats Model with Monocrotaline-Induced Pulmonary Hypertension: Investigating the Signaling Pathway of NFκB, OPG, Runx2, and P-selectin in Heart |
| Safranal | 📋 | | | | 20013822 | Hypotensive Effect of Aqueous Saffron Extract (Crocus Sativus L.) and Its Constituents, Safranal and Crocin, in Normotensive and Hypertensive Rats |
| Sage | 📋 | ✍ | ⛔ | | 31987228 | Efficacy of Salvia officinalis extract on the prevention of insulin resistance in euglycemic patients with polycystic ovary syndrome: A double-blinded placebo-controlled clinical trial |
| Schisandra | 📋 | ✍ | ⛔ | | 18983904 | The Mechanism of Vasorelaxation Induced by Schisandra Chinensis Extract in Rat Thoracic Aorta |
| Scutellarein | 📋 | | | | 40189160 | Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase |
| Scutellarin | 📋 | | | | 34414202 | Oral Scutellarin Treatment Ameliorates Retinal Thinning and Visual Deficits in Experimental Glaucoma |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 27522605 | Effect of seabuckthorn seed oil in reducing cardiovascular risk factors: A longitudinal controlled trial on hypertensive subjects |
| Senolytics | 📋 | | | | 35554866 | Elimination of Senescent Cells Attenuates Obesity-Induced Increase in Sympathetic Nerve Activity |
| Sesamin | 📋 | ✍ | | | 35311241 | The Effects of Sesamin Supplementation on Obesity, Blood Pressure, and Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Soy Protein | 📋 | ✍ | ⛔ | | 38174000 | Protein supplementation: the double-edged sword |
| Soybean Oil | 📋 | | ⛔ | | 37461334 | Effect of lard plus soybean oil on blood pressure and other cardiometabolic risk factors in healthy subjects: a randomized controlled-feeding trial |
| Spearmint | 📋 | | ⛔ | | 32340314 | A Dietary Combination of Forskolin with Homotaurine, Spearmint and B Vitamins Protects Injured Retinal Ganglion Cells in a Rodent Model of Hypertensive Glaucoma |
| Spermidine | 📋 | | | | 38552292 | Spermidine attenuates monocrotaline-induced pulmonary arterial hypertension in rats by inhibiting purine metabolism and polyamine synthesis-associated vascular remodeling |
| Spices | 📋 | | | | 34510174 | Herbs and spices at a relatively high culinary dosage improves 24-hour ambulatory blood pressure in adults at risk of cardiometabolic diseases: a randomized, crossover, controlled-feeding study |
| Star Fuit | 📋 | | ⛔ | | 20937374 | Hypotensive effect of aqueous extract of Averrhoa carambola L. (Oxalidaceae) in rats: an in vivo and in vitro approach |
| Tamarind | 📋 | | ⛔ | | 37571339 | Sour Tamarind Is More Antihypertensive than the Sweeter One, as Evidenced by In Vivo Biochemical Indexes, Ligand-Protein Interactions, Multitarget Interactions, and Molecular Dynamic Simulation |
| Tannic Acid | 📋 | ✍ | ⛔ | | 16939706 | Role of nitric oxide in the vasorelaxant and hypotensive effects of extracts and purified tannins from Geum japonicum |
| Tanshinone | 📋 | | | | 35673916 | [Tanshinone IIA alleviates monocrotaline-induced pulmonary hypertension in rats through the PI3K/Akt-eNOS signaling pathway] |
| Tetrahydrocurcumin | 📋 | ✍ | | | 36971089 | Tetrahydrocurcumin Add-On therapy to losartan in a rat model of diabetic nephropathy decreases blood pressure and markers of kidney injury |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 27800486 | First Report of Eurycoma longifolia Jack Root Extract Causing Relaxation of Aortic Rings in Rats |
| Trans-Resveratrol | 📋 | | | | 32758568 | Effect of trans-resveratrol on dexamethasone-induced changes in the expression of MMPs by human trabecular meshwork cells: Involvement of adenosine A 1 receptors and NFkB |
| Trehalose | 📋 | | ⛔ | | 34500062 | Trehalose, a natural disaccharide, reduces stroke occurrence in the stroke-prone spontaneously hypertensive rat |
| UDCA | 📋 | ✍ | ⛔ | | 39984850 | The effects of ursodeoxycholic acid on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials |
| Urolithins | 📋 | | | | 39125817 | Urolithin A Protects against Hypoxia-Induced Pulmonary Hypertension by Inhibiting Pulmonary Arterial Smooth Muscle Cell Pyroptosis via AMPK/NF-κB/NLRP3 Signaling |
| Vitamin B Complex | 📋 | | ⛔ | | 32340314 | A Dietary Combination of Forskolin with Homotaurine, Spearmint and B Vitamins Protects Injured Retinal Ganglion Cells in a Rodent Model of Hypertensive Glaucoma |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 36965328 | Folate, vitamin B6, and vitamin B12 intakes are negatively associated with the prevalence of hypertension: A national population-based study |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 36965328 | Folate, vitamin B6, and vitamin B12 intakes are negatively associated with the prevalence of hypertension: A national population-based study |
| Vitamin B8 | 📋 | ✍ | ⛔ | | 32179885 | Maternal Supplementation of Inositols, Fucoxanthin, and Hydroxytyrosol in Pregnant Murine Models of Hypertension |
| Vitamin K2 mk-7 | 📋 | ✍ | | | 40077685 | Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women |
| Vitexin | 📋 | | | | 39079512 | The protective effect of vitexin on hypertensive nephropathy rats |
| Wasabi | 📋 | | ⛔ | | 36360048 | Wasabi ( Eutrema japonicum) Reduces Obesity and Blood Pressure in Diet-Induced Metabolic Syndrome in Rats |
| Watermelon | 📋 | | ⛔ | | 37369281 | Watermelon consumption decreases risk factors of cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials |
| Wheat | 📋 | | ⛔ | | 38814365 | Associations between whole grains intake and new-onset hypertension: a prospective cohort study |
| Yerba Mate | 📋 | ✍ | ⛔ | | 40263915 | Yerba Mate (Ilex paraguariensis St. Hill.) Tea May Have Cardiometabolic Beneficial Effects in Healthy and At-Risk Subjects: A Randomized, Controlled, Blind, Crossover Trial in Nonhabitual Consumers |
| Yogurt | 📋 | | ⛔ | | 34494630 | Probiotic yogurt blunts the increase of blood pressure in spontaneously hypertensive rats via remodeling of the gut microbiota |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 31356404 | Association Between Dietary Carotenoid Intakes and Hypertension in Adults: National Health and Nutrition Examination Survey 2007-2014 |
